Controlled release of bioactive molecules from porous materials regulates cellular functions
Living cells are recognized as an ultimate assembly of molecules. As its active matter, a living cell regulates its function by intracellular signalling molecules and communicates to each other by extracellular signalling molecules. We develop porous materials that accommodate important signalling molecules (nitric oxide, carbon monoxide, or glutamic acid) and give materials a chemical trick to release these signalling molecules by external trigger. This new type of porous materials are demonstrated to directly regulate the biological activity of living cells. We are currently developing these materials for therapeutic applications.
シグナル分子を時空間的に制御する材料をつくる
細胞は、分子集合体の究極的なかたちです。その生き物としての活動は、もちろん分子で行われています。その機能は細胞内のシグナル分子で制御され、細胞と細胞の間の情報伝達は細胞外のシグナル分子を介して行われています。私たちは、一酸化窒素、一酸化炭素、グルタミン酸といったシグナル小分子を閉じ込める多孔性材料をつくり、ちょっとしたトリック（外部からの信号）を使うことで、必要な時に、必要な場所で放出できるようにしました。この材料で細胞の活性を直接変化させることを示しました。現在は、この材料を使った医療応用に挑戦しています。
<Review>
“Porous materials as carriers of gasotransmitters towards gas biology and therapeutic applications”Chem. Commun. 2020, 56, 9750-9766.
<Original papers>
“Localized cell stimulation by nitric oxide using a photoactive porous coordination polymer platform”
Nature Commun. 2013, 4, 2684.
“L-Glutamic acid release from a series of aluminium-based isoreticular porous coordination polymers”
J. Mater. Chem. B 2015, 3, 4205-4212.
“Light-induced nitric oxide release from physiologically stable porous coordination polymers”
Dalton Trans. 2015, 44, 15324-15333.
“Light responsive metal-organic frameworks as a controllable CO-releasing cell culture substrate”
Chem. Sci. 2017, 8, 2381-2386.
“Coordination Modulation Method to Prepare New MOF-based CO-Releasing Materials”
ACS Appl. Mater. Interfaces 2018, 10, 31158-31167.