Controlled release of bioactive molecules from porous materials regulates cellular functions

Living cells are recognized as an ultimate assembly of molecules. As its active matter, a living cell regulates its function by intracellular signalling molecules and communicates to each other by extracellular signalling molecules. We develop porous materials that accommodate important signalling molecules (nitric oxide, carbon monoxide, or glutamic acid) and give materials a chemical trick to release these signalling molecules by external trigger. This new type of porous materials are demonstrated to directly regulate the biological activity of living cells. We are currently developing these materials for therapeutic applications.




“Porous materials as carriers of gasotransmitters towards gas biology and therapeutic applications”Chem. Commun202056, 9750-9766.

<Original papers>

“Localized cell stimulation by nitric oxide using a photoactive porous coordination polymer platform”
Nature Commun. 2013, 4, 2684.

“L-Glutamic acid release from a series of aluminium-based isoreticular porous coordination polymers”
J. Mater. Chem. B 20153, 4205-4212.

“Light-induced nitric oxide release from physiologically stable porous coordination polymers”
Dalton Trans. 201544, 15324-15333.

“Light responsive metal-organic frameworks as a controllable CO-releasing cell culture substrate”
Chem. Sci. 2017, 8, 2381-2386.

Coordination Modulation Method to Prepare New MOF-based CO-Releasing Materials
ACS Appl. Mater. Interfaces 201810, 31158-31167.