Written by Our research on the controlled NO release from RhMOP and coordination polymer particles (CPPs) has been published in the Journal of Materials Chemistry B!! Thanks to all the authors for their tremendous contribution!! This work is also Thiago’s first paper during his Ph.D. program, congratulations!!
The exogenous administration of nitric oxide (NO) is considered a potential therapeutic treatment against a great variety of diseases due to its significant role in multiple physiological functions. We proposed a new molecular material based on robust metal-organic polyhedra (MOP) for NO release. We selected dirhodium paddlewheel complex-based cuboctahedral MOPs (RhMOP) and demonstrated their remarkable ability to store and release NO in response to changes in light and humidity. Furthermore, coordinating either monotopic or ditopic imidazole organic linkers at the axial site of RhMOP produces surface-functionalized RhMOP or CPPs, respectively. This enables us to regulate the release of biologically relevant amounts of NO, making these materials suitable for application in cell biology and medical research.
“Dual photoresponsive & water-triggered nitric oxide-releasing materials based on rhodium-based metal-organic polyhedra”
Francisco J Carmona, Thiago Negrão Chuba, Elí Sánchez-González, Jenny Pirillo, Yuh Hijikata, Shuhei Furukawa
J. Mater. Chem. B 2023, in press. DOI: 10.1039/D3TB02162A
(Chemrxiv Preprint DOI: 10.26434/chemrxiv-2023-n72r8)